Interaction of six candidate genes in essential hypertension
نویسندگان
چکیده
منابع مشابه
Interaction of six candidate genes in essential hypertension.
We explored the interaction of 6 candidate genetic mutations in essential hypertension (EH). The mutations AGT M235T, ACE I/D, eNOS Glu298Asp, ET-2 A985G, ANP T2238C, and NPRC A-55C were detected using a genechip microarray in 100 patients with EH and 97 controls from the Han population living in the Yunnan Province of China. Risks of EH were evaluated with respect to a combination of these gen...
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Essential hypertension (EH) is a polygenic and multifactorial disorder that results from genetic and/or environmental factors (Lifton et al., 2001). This disease has no identifiable origin, but results from a disturbance of systems regulating blood pressure (BP) such as several circulating and local neurohumoral and vasoactive factors. Genetic variations of these factors could play a role in th...
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Analysis of candidate genes of QTL and chromosomal regions for essential hypertension in the rat model
This is an in silico analysis of quantitative trait loci (QTLs), genes, polymorphisms, and chromosomal regions regulating hypertension in the rat genome. Utilizing PGmapper, a program that matches phenoltypes to genes, we identified 266 essential hypertension-associated genes (HyperA), and 83 of these genes contain known hypertension-associated polymorphisms (HyperAP). The majority of HyperAP h...
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Hypertension (HT) is an important public health problem affecting more than 60 million people in the US and over a billion people worldwide. Essential hypertension (high blood pressure with no obvious causes) accounts for 95% of the cases. The biological process of blood pressure regulation involves multiple physiological pathways, each of which may be affected by multiple genes. Therefore, it ...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2014
ISSN: 1676-5680
DOI: 10.4238/2014.october.20.14